Christopher Lupfer

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Assistant Professor

Academic Interests

  • Immunology and innate immune signaling pathways
  • Host pathogen interactions
  • Viral-Bacterial coinfections and hyper-inflammation
  • Anti-viral and anti-inflammatory drug development.

Top Scholarly Accomplishments

  • Lupfer C, Anand PK, Liu Z, Stokes K, Vogel P, Lamkanfi M, KannegantiT-D. (2014) Reactive oxygen species regulate caspase-11 expression and activation of the non-canonical NLRP3 inflammasome during enteric pathogen infection. PLOS Pathogens.  DOI: 10.1371/ journal.ppat.1004410
  • Lupfer C, Thomas PG, Kanneganti T-D. (2014) NOD2 dependent DC activation is necessary for innate immunity and optimal CD8+ T cell responses to influenza A virus infection. J. Virology. 88(16):8946-55
  • Lupfer C, Thomas PG, Anand PK, Vogel P, Milasta S, Martinez J, Huang G, Green M, Kundu M, Chi H, Xavier RJ, Green DR, Lamkanfi M, Dinarello CA, Doherty PC & Kanneganti T-D. (2013) Receptor interacting protein kinase 2-mediated mitophagy regulates inflammasome activation during virus infection. Nature Immunology. 14(5):480-8.
  • Ellebedy AH, Lupfer C, Ghoneim HE, DeBeauchamp J, Kanneganti TD, Webby RJ. (2011) Inflammasome-independent role of the apoptosis-associated speck-like protein containing CARD (ASC) in the adjuvant effect of MF59. Proc Natl Acad Sci U S A. 108(7):2927-32
  • Lupfer C, Kanneganti TD. (2013) Unsolved Mysteries in NLR Biology. Front Immunol. 4:285.  Lupfer C, Kanneganti T-D. (2013) The expanding role of NLRs in antiviral immunity. Immunological Reviews. 255(1):13-24. 

Previous Experience

  • 2014—Adjunct Assistant Professor in the Department of Biology, Rhodes College, Memphis, TN.
  • 2009–2015: Postdoctoral Fellow, St. Jude Children’s Research Hospital, Memphis, TN


Phoenix, AZ


  • Camping
  • Fishing
  • Hunting
  • Spending time with my family

Future Goals and Aspirations

Every day I seek to become an exceptional teacher, mentor and researcher. I measure my success by the number of students and trainees that succeed in their careers and aspirations. In my research, my goal is to improve the scientific community's understanding of how improper immune responses to infections can lead to more severe disease, and my goal is to find new therapies to treat such diseases. 

Life Outside of the University

Much of my time away from work is spent with my wife and five children. We enjoy going to the park, going camping and playing board games. I sing in my church choir and teach Sunday School too. Occasionally, I even find time to sleep.

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