Missouri State University

Sean Newton, PT, PhD

Associate Professor

Education

Dr. Newton joined the physical therapy faculty at Missouri State University in January 2001. He received his MS (1984) and Ph.D. (1989) in Physiology from Southern Illinois University, School of Medicine and his MSPT degree from the University Of Mobile (2000). He has been involved in academia for 23 years, teaching PT students for 12 of those years.  He holds experience in traditional lecture based instruction and in problem-based instruction.  At Missouri State University, Dr. Newton directs or assists instruction in:  PTE 707 Medical Human Anatomy; PTE 713 Human Development and the Life Cycle; PTE 714 Imaging Analysis in PT Practice; PTE 744 Patient Management Cardiovascular and Pulmonary Problems; PTE 720 Neuroanatomy/Neuroscience; PTE 730 Motor Control/Motor Learning; PTE 873 Patient Management Advanced Differential Diagnosis; and, PTE 883 Patient Management Critical Integration & Analysis. Dr. Newton enjoys teaching in both classroom and laboratory settings.

Research and Teaching

Dr. Newton has published articles in the areas of reproductive cell biology, toxicology, circadian rhythms, and neuroendocrinology. He has in the past managed three successful NIH funded laboratories. His current interests are the physiological effects of physical therapy modalities, the neurological and vascular effects of complex regional pain syndrome (CRPS), and sympathetic interaction on vascular compromise. Currently, Dr. Newton is working on two books, the first is a “Handbook of Essential Neuroscience” and the second is a “Textbook of Peripheral Nerve Anatomy”.

Publications and Presentations

Bagchi D., Tran MX, Newton S., Bagchi M., Ray SD, Kuszynski CA and SJ Stohs: Chromium and Cadmium induced oxidative stress and apoptosis in cultures J774A.1 macrophage cells. In vitro and Molecular Toxicology 11: 171-18, 1998

Cocker, CM Church MK, Newton SC, and RG Townley: Glucocorticoids inhibit proliferation and interleukin 4 and 5 secretion by aeroallergens- specific T-helper type 2 cell lines Ann. Allergy asthma Immunol. 80:509-516, 1998

Newton SC, LL Murphy and A. Bartke. In Vitro Effects of Psychoactive and Non-psychoactive Cannabinoids on Immature Rat Sertoli Cell Function. Life Sciences 53:1429-1437, 1993.

Newton, SC, OW Blaschuk and CF Millette. N-cadherin mediates Sertoli cell-spermatogenic cell adhesion. Developmental Dynamics 197: 1-13, 1993.

Nitta H, D Brunick, RA Hess, SC Newton, CF Millette, Y Osawa, Y Shizuta, K Toda and J Bahr. Germ Cells of the Mouse Testis Express Aromatase, the Estrogen Synthesizing Enzyme. Endocrinology 132:1396-1401, 1993.

Newton SC, MJ Welsh and A Bartke. Effects of age, photoperiod and Follicle-Stimulating Hormone on Lactate Production by Cultured Sertoli Cells from Prepubertal Siberian Hamsters (Phodopus sungorus). J. Reprod. Fert. 95:87-95, 1992.

Newton SC, CF Millette. Sertoli Cell Plasma Membrane Polypeptides Involved in Spermatogenic Cell-Sertoli Cell Adhesion. J. Androl. 13:160-171, 1992.

Newton SC and CF Millette. Quantification of an in vitro Cell-Cell Adhesion Assay Using Interactive Laser Scanning Cytometery. Cytometery 13:209-219, 1992.

Bartke A, A Mayerhofer, S. Newton, D. Mayerhofer, S. Majumdar and V. Chandrashekar. Alterations in the Control and Function of Somatic Cells in the Testis Associated with Suppression of Spermatogenesis in Seasonal Breeders. Annl. N.Y. Acad. Sci. 637: 143-151, 1991.

Murphy LL, SC Newton, J. Dhali and D. Chavez. Evidence for a Direct Anterior Pituitary Site of Delta-9-Tetrahydrocannabinol Action. Pharmacol. Biochem. Behavior 40:603-607, 1991.

Bartke A, A Mayerhofer and S. Newton. Photoperiod-Dependent Changes in Neuroendocrine Function in Seasonal Breeders. Proceedings of the International Workshop on Sites of Action and Effects of Pineal Hormones. Adv. Pineal Res. 4: 197-204, 1990

Bartke A, S. Newton and D. Mayerhofer. Effects of Exposure to Different Photoperiod in Vivo on the Responses of Testicular Cells to Follicle-Stimulating Hormone in Vitro. 3rd International Workshop on Bioelectromagnetics and the pineal. Madrid, Spain PP. 123-132, 1989.

Newton SC, A Bartke and A Mayerhofer. Dopamine and Isoproterenol Stimulate lactate Secretion from Sertoli cell cultures isolated from immature Golden hamsters. Euroendocrinol. Lett. 11: 207-214, 1989

Steger RW, V Chandrashekar, A Bartke, J Wortsman, SC Newton, RC Smallridge and J Dietrich. Effects of Elevated Gonadotropins Levels on Thyroid Function in the Male Rat. Life Science 45:85-90, 1989

Nequin LG and SC Newton. Influence of Experimental Design on the Response of the Rat testes to Exogenous Gonadotropins: Induced Rhythms? J. Interdisc. Cycle Res. 17:81-87

Presentations:

Newton SC, Miller TM, Robinson BS. Effects of Monochromatic infrared Photo Energy on Early Stage Diabetic Peripheral Neuropathy. Poster at the annual Missouri Physical Therapy Association Meeting April 2007

Abstracts:
TE Wilson, NT Kuipers, EA McHugh, S Newton and CA Ray. Is Vestibular Activation a Nonthermal Modulator of Skin Blood Flow or Sweating? Submitted to American College of Sports Medicine 2004

LL Murphy, SC Newton, S Robinson, G Barker, M Snow and MJ Horacek. RGD peptide increases, and anti beta 1 integrin decreases, prolactin secretion from rat anterior pituitary gland cells in vitro. FASEB journal 10 (3) abst. 2326 page A402, 1996

SC Newton, D. Adams, J. Souders, S. Wallentine and MJ Horacek. Matrigel increases intracellular beta tubulin in GH3 cells. FASEB Journal 10 (3): abst. 2328 page A402, 1996

Tran MX, SJ Stohs, S Newton, D Bagchi, M Bagchi, L Tang, SD Ray. Cadmium and chromium induced oxidative stress and programmed cell death in cultured j774A.1 macrophage cells 1996 SOT annual meeting

Newton SC and MJ Horacek. A monoclonal antibody against rat Sertoli cell surface polypeptide (SGAM) inhibits the formation of adenohyphyseal cell aggregates in vitro. Mol. Biol. Cell 5:82a abst. 476, 1994

Newton SC, Raychoudhury SS and CF Millette. Hormonal regulation of Sertoli cell-germ cell adhesion molecules (SGAM). Mol. Biol Cell 4:28A abst. 161, 1993

Newton SC, Knapp L, Washington L and CF Millette. Monoclonal Antibodies to Sertoli Cell Surface Polypeptides Inhibit Germ Cell-Sertoli Cell Adhesion in vitro. FASEB J. 6 (5) pt II:A1920, 1992.

Millette CF and SC Newton and OW Blaschuk. Antiserum Against N-Cadherin Inhibits in vitro Sertoli cell-Germ cell Adhesion. Anatomical Rec. 232 (4):62A, 1992.

Newton SC and CF Millette. Sertoli Cell Plasma Membrane Polypeptides Involved in Spermatogenic Cell-Sertoli Cell Adhesion. Biol. Reprod. 44 supplement :p93, 1991

Newton SC and CF Millette. Spermatogenic Cell-Sertoli Cell Adhesion Assay: Quantification Using the ACAS 570 Interactive Laser Cytometer. J. Cell Biol. 111: abstr 2247 page 404a,1990.

Murphy LL and SC Newton. Delta-9-tetrahydrocannabinol Antagonism of Estradiol Effects on Basal and Dopamine-modulated Prolactin Secretion from Rat Anterior Pituitary cells. 1990 Endocrine Society meeting Abstr 667 p191

Ghosh PK, SC Newton and A. Bartke. Lactic Acid and Transferrin Production by Sertoli Cells: Effect of Alpha-2u-globulin. J. Androl. 11: Abstr. 39, 1990

Newton SC. lactate Secretion by Sertoli Cells Isolated from Djungarian Hamsters Exposed to Different Photoperiod. Biol. Reprod. 40: Suppl. Abstr. 186, 1989.

Mayerhofer A, S Newton, A Bartke and T Began. Effects of Histamine on the Function of Leydig Cells and Sertoli Cells in the Immature Golden Hamster. J. Androl. 10: Abstr. 99, 1989.

Newton SC, A Mayerhofer and A Bartke. Interaction of Photoperiod and Vitamin D on FSH-Induced Lactate Secretion in Sertoli Cell Cultures Isolated from Djungarian Hamsters (Phodopus sungorus). J. Androl. 10: Abstr. 96, 1989.

Newton S, A Mayerhofer and A. Bartke. Histamine Blocks Stimulating Action of FSH on Lactate Secretion by Cultured Djungarian Hamster Sertoli cells. Trans. IL. Acad. Sci. 81:Suppl. p46 abstr. 56, 1988

Newton SC, A. Bartke and LL Murphy. Synergistic Effects of Delta-9-Tetrahydrocannabinol, Follicle Stimulating Hormone and Epinephrine on Lactate Secretion by Sertoli Cells. APS/ASPET Joint meeting 1988: A51, Abstr 39.16.

Newton SC and LG Nequin. Circadian Sensitivity of the Rat Testis to Gonadotropin is Altered by Experimental Design. Fed. Proc. 45(3):A896, 1986.

 

Clinical Experience and Service

Dr. Newton serves on numerous departmental and university committees. Currently he is the Physical Therapy representative to the Graduate Council. Additionally Dr. Newton serves as President of the Southwest District of the Missouri Physical Therapy Association. Dr. Newton's clinical practice consists of the treatment of individuals with diabetic peripheral neuropathy and chronic pain.